It's easy to save searches using My NCBI. When you save a search, you can choose to manually check for new references or schedule e-mail delivery of new papers added to PubMed which match your search criteria. To save a search:
Run your search.
Click "Create Alert."
Name the Saved Search.
OR
Choose "yes" when asked "Would you like to receive e-mail updates of new search result?" if you'd prefer to have new references sent to you via email. Specify the frequency, format, and maximum number of citations you would like to receive per email alert.
Click "Save."