Make sure you have the files necessary to deposit to NIHMS. You need to have all files for the paper, including:
What format files can you use for the manuscript?
Log in to the NIHMS website
There are links to sign-in help and reminders on the bottom of the page.
Your NIHMS "home page" has the My Manuscripts heading. In the main section of this page you will see any manuscripts that may be awaiting your attention.
Before submitting a new manuscript, it's wise to search the NIHMS system to see if your paper might already be in process, if it was deposited by a publisher or by a colleague.
On the right side of the page, use the search box under the Submit New Manuscript button to search NIHMS by PMID, PMCID or NIHMSID. Click the magnifying glass icon to search.
If your search doesn't retrieve any results, or if your paper doesn't have a PMID yet, you can simply click the Submit New Manuscript button to start the process of depositing your paper.